How Do You Use Artemether?

What is the mechanism of action of artemether?

Lumefantrine binds to hemin produced during hemoglobin breakdown, preventing detoxification to crystalline malaria pigment (hemozoin).

During the same process, the perOXide group in artemether binds to heme and releases toxic free-radicals..

How long does artemether lumefantrine stay in the body?

Lumefantrine has an elimination half-life of approximately six days in healthy volunteers [8] and three to four days in patients with Plasmodium falciparum malaria [7, 9] (Table 1).

Can you take fruits when taking malaria drugs?

High fibre foods like whole grain cereals must be avoided by malaria patients. Instead, the intake of fruits and pulses should be increased as they provide adequate nutrition. Eating fried and processed foods, junk oily and spicy foods can aggravate nausea and can disturb the digestion process in the body.

What is another name for artemether and lumefantrine?

Artemether/lumefantrine, sold under the trade name Coartem among others, is a combination of the two medications artemether and lumefantrine. It is used to treat malaria caused by Plasmodium falciparum that is not treatable with chloroquine. It is not typically used to prevent malaria. It is taken by mouth.

How do you administer artemether lumefantrine?

Dosage and duration – The treatment is administered 2 times daily for 3 days. On D1, the first dose is given at 0 hour and the second dose at 8-12 hours. Subsequent doses on D2 and D3 are given 2 times daily (morning and evening).

How long does artemether stay in the body?

Artemether is metabolized in the human body to the active metabolite, dihydroartemisinin, primarily by hepatic enzymes CYP3A4/5. Both the parent drug and active metabolite are eliminated with a half-life of about 2 hours.

What is the work of artemether?

This medication is used to treat malaria in adults and children. The two ingredients in this medication belong to a class of drugs known as antimalarials. Malaria is an infection caused by mosquito bites received while traveling or living in regions of the world where malaria is common.

Does milk affect malaria drugs?

Milk has been used as a vehicle for the delivery of antimalarial drugs during clinical trials to test for a food effect and artefenomel (OZ439) showed enhanced oral bioavailability with milk.

What is the difference between artesunate and artemether?

Artesunate is the water soluble sodium hemisuccinyl ester, whilst artemether is the lipid soluble methyl ether of dihydroartemisinin. Both artesunate and artemether are metabolized in vivo to the highly active antimalarial metabolite, dihydroartemisinin (DHA) [5, 6].

Why is Artemether not given IV?

Intravenous (iv) or intramuscular (im) artesunate, a water-soluble artemisinin derivative, and im artemether are increasingly used for the treatment of severe malarial patients. Unlike artesunate, there is no iv preparation of artemether, as artemether is water insoluble and requires to be dissolved in edible oils.

Is Lumefantrine an antibiotic?

The other is lumefantrine, a broad-spectrum antibiotic that stays in the body for about seven days. Coartem is the most effective treatment for Plasmodium falciparum malaria, the more lethal form. Artemether is a very potent, but fast-clearing drug, which is why you take both it and lumefantrine.

Where does Coartem or riamet work to kill the parasite?

This medication is used to kill the malaria parasites living inside red blood cells. In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in the liver. Both treatments may be needed for a complete cure and to avoid the return of infection (relapse).

What are the side effect of artemether?

Common side effects may include:headache, dizziness;fever, cough, feeling weak or tired;muscle pain, tenderness, or weakness;joint pain;vomiting; or.loss of appetite.

Can I take malaria drugs with antibiotics?

Antibiotics can be used in areas where parasites are resistant to standard anti-malarial drugs. This difference in modes of action also implies that antibiotics can be a good partner for combination.

Does malaria cause sleeplessness?

Early symptoms of malaria can include irritability and drowsiness, with poor appetite and trouble sleeping. These symptoms are usually followed by chills, and then a fever with fast breathing.

How do you take artemether?

The combination of artemether and lumefantrine comes as a tablet to take by mouth. It is usually taken twice a day for 3 days as instructed by your doctor. Always take artemether and lumefantrine with food. If you are not able to eat, contact your doctor.

Why is Artemether combined with lumefantrine?

To overcome the problems of monotherapy artemether, a derivative of artemisinin, has been combined with lumefantrine, an anti-malarial drug developed in China. Compared to artemether, lumefantrine has a slower onset of action, but a more sustained effect against the parasite.

Which are the best anti malaria tablets?

When several different drugs are recommended for an area, the following table might help in the decision process.Atovaquone/Proguanil (Malarone)Chloroquine.Doxycycline.Mefloquine.Primaquine.Tafenoquine (ArakodaTM)